You can't stop itching "down there. Thankfully, most things that cause this condition are not serious, but you may need a trip to your gynecologist to figure out what is going on. Vaginal itching and burning often are caused by a vaginal infection. One of the most common of these is a yeast infection. Yeast is an organism that lives in the vagina, but in certain conditions, it can overgrow, causing intense itching and thick vaginal discharge.